In case you have to Design or implement a VMware Horizon Infrastructure for your Customer or Company for instance, first of all you need a good understanding about Network, Ports, Protocols and the overall communication flow to make your Design or Implementation a success. Another important piece is experience, do never underrate experience in that case. Really helpful in that case is a good overview about all Network Ports, Protocols and a clearly diagram which makes it easier for you to understand the communication flows. In VMware Horizon 7 a lot of improvements was made and additionally the Blast Extreme protocol was integrated.
Here a awesome overview, please take a look.